021-51111890
购物车（）
sales@molnova.cn
SR 48692
CAS No. 146362-70-1
SR 48692 ( Meclinertant | SR48692 | SR-48692 )
产品货号. M11989 CAS No. 146362-70-1
一种有效的、选择性的、口服活性的神经降压素受体非肽拮抗剂，IC50 为 0.99 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥13397 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称SR 48692
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述一种有效的、选择性的、口服活性的神经降压素受体非肽拮抗剂，IC50 为 0.99 nM。
-
产品描述A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity; blocks K(+)-evoked release of [3H]dopamine stimulated by neurotensin in guinea pig striatal slices with IC50 of 0.46 nM, competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization with pA2 of 8.13 in H29 cells; reverses the turning behavior induced by intrastriatal injection of neurotensin in mice.Lung Cancer Phase 2 Clinical.
-
体外实验——
-
体内实验——
-
同义词Meclinertant | SR48692 | SR-48692
-
通路GPCR/G Protein
-
靶点Neurotensin Receptor
-
受体Neurotensin Receptor
-
研究领域Cancer
-
适应症Lung Cancer
化学信息
-
CAS Number146362-70-1
-
分子量587.073
-
分子式C32H31ClN4O5
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(NC1(C(O)=O)[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C4=NN(C5=CC=NC6=CC(Cl)=CC=C56)C(C7=C(OC)C=CC=C7OC)=C4
-
化学全称(1r,3r,5r,7r)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)adamantane-2-carboxylic acid
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Dubuc I, et al. Br J Pharmacol. 1994 Jun;112(2):352-4.
2. Steinberg R, et al. Neuroscience. 1994 Apr;59(4):921-9.
3. Brouard A, et al. Eur J Pharmacol. 1994 Mar 3;253(3):289-91.
4. Gully D, et al. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):65-9.
产品手册
关联产品
-
Neurotensin(8-13)
Neurotensin (8-13) is a neuropeptide that corresponds to the C-terminal residues 8-13 of neurotensin that binds to rat synaptic membranes with a Ki value of 13 nM.1 It induces contraction of guinea pig ileum (EC50 = 25 nM) and induces contraction of rat fundus equipotently to full length neurotensin (EC50s = 1.29 and 1.58 nM, respectively).
-
SR 142948
SR 142948 是一种神经降压素 (NT) 受体拮抗剂。
-
SR 48692
一种有效的、选择性的、口服活性的神经降压素受体非肽拮抗剂，IC50 为 0.99 nM。
